Lab #4: The Biomolecule of Vampirism

I searched for draculin, a protein found in the saliva of Desmodus rotundus, otherwise known as the common vampire bat. The specific protein I chose to examine was Draculin-1, partial [Desmodus rotundus]. The accession number for this protein is JAA65087.1. The amino acid sequence for this protein is:
 "1 mkllflalls llalgpslaa rrrgvrwcti skpeaakcsk lqqnlkrvrg pslscisrks
       61 yleciqaiaa kradamslda glvyeagqdp yrlrpvaaev ygtegaprth yyavalvkkd
      121 snlqlnqlqg vrschtglnr sagwkipvgt lrpylgwagp paplqeavan ffsascvpca
      181 dgnqypnlcr lcagtgadkc acsskepyfg ysgafkclkd gagdvafvkd stvfenlpnk
      241 aerdqyellc pdntrkpvde feqchlarvp shavvarsvg gkedsiwrll skaqekfgkg
      301 tsgsfqlfss ppgqkdllfk dgaqgflrip srvdaelylg psyltviknl ngigsrggdp
      361 ggpglcgarw aqrscasass gvaramgq," 
with the first 10 amino acids being methionine, lysine, leucine, leucine, phenylalanine, leucine, alanine, leucine, leucine, and serine.
The nucleotide sequence which codes for this form of draculin is:
"1 atgaagctcc tcttccttgc actgctgtcc ctcctggccc tcgggccgag tctggctgcc
       61 cgcaggagag gtgttcgatg gtgcaccata tcaaaaccag aggcagcaaa atgctctaaa
      121 ctgcaacaga atctaaaacg agtgcgtggc ccctctctct cctgcataag cagaaagtcc
      181 tacctggaat gtatccaggc catcgcggcg aaaagggcag atgccatgag ccttgatgca
      241 ggtctggtgt acgaggcagg acaggacccg tacagactgc ggcctgtggc agcagaggtc
      301 tacgggaccg agggggcacc gcggacgcac tattacgctg tggccctggt gaaaaaggac
      361 agcaacttgc aactgaacca gctgcaaggc gtgaggtcct gccacactgg cctcaacagg
      421 tccgccgggt ggaaaatccc tgtgggcacg ctccgtccgt acctgggctg ggcagggcca
      481 cctgcacccc tccaggaagc tgtggccaac ttcttctccg ctagctgtgt tccctgtgca
      541 gatggcaacc agtaccccaa cctgtgtcgc ttgtgtgcgg ggacaggggc agataaatgt
      601 gcctgctcct ccaaggaacc gtactttggc tactccggtg ccttcaagtg tctgaaagat
      661 ggggctggag acgtggcttt tgtcaaggac agtacggtgt ttgagaacct gccaaacaag
      721 gccgagagag accagtatga gctgctctgc ccagacaaca cccgaaagcc ggtggatgag
      781 tttgagcagt gccacctggc ccgggtccct tctcatgcag ttgtggcccg aagcgtgggt
      841 ggcaaggagg actcgatctg gaggcttctc agcaaggcac aggagaagtt tggaaaaggc."
 
Reference:
B.G. Fry. "Molecular phylogeny and evolution of the proteins encoded by the common vampire bat (Desmodus rotundus) submaxillary glands." Unpublished.  
 
 

Comments

  1. Hi Caleb,
    Your protein choice is definitely interesting! Just the name alone made me wonder if that name derived from the fictional character, or vice versa. I have heard that draculin is used in the medical field since it can help with blood clots, but I do not know if it is being used legally or not.

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  2. Wow, a thrilling pic. A quick search on Wikipedia explained how this protein works as an anticoagulant in order to keep the blood of the victim flowing. Just a couple days I saw a video on penguins and how this mammal is a common threat to them. I wonder what the phylogeny tree for these bats look like and if once they obtained this draculin protein if that part of the clade radiated from there.

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