Blog Post 2 gp60, partial [Cryptosporidium parvum] Deborah Haney
What protein did you search for?
I searched the term “dairy goats” and came up with glycoprotien from
Cryptosporidium parvum.
Cryptosporidium parvum.
What specific protein did you select (be careful here – a search for insulin will
also give you results for insulin receptors and many other insulin-related molecules)?
also give you results for insulin receptors and many other insulin-related molecules)?
Cryptosporidium parvum is an organism that causes goats to become ill, symptoms
being scours, weight loss, poor digestion, weakness, abdominal pain, not eating,
dehydration, fever, and death. It’s a protozoa that give similar symptoms as coccidia,
a common disease in goat kids under stress (like during weaning), but crypto doesn’t
respond to coccidiostats or any other medications currently licensed for goats. Crypto
is more common in calves than kids so many goat owners are unfamiliar with it but we
had a case with our first bottle baby. Fortunately, he is fine.
being scours, weight loss, poor digestion, weakness, abdominal pain, not eating,
dehydration, fever, and death. It’s a protozoa that give similar symptoms as coccidia,
a common disease in goat kids under stress (like during weaning), but crypto doesn’t
respond to coccidiostats or any other medications currently licensed for goats. Crypto
is more common in calves than kids so many goat owners are unfamiliar with it but we
had a case with our first bottle baby. Fortunately, he is fine.
What is the amino acid sequence that codes for this protein? Cut and paste from the database and put these search results (or no more than the first 15 typed lines) in your lab report. Translate the first 10 amino acids from this code into the amino acid names.
>KT235713.1 Cryptosporidium parvum isolate Dd12 gp60 (gp60) gene, partial cds
1 savfsapavp lrgtlkdvsv egssssssss ssssssssss sststvaptp kkertgeevg
61 npgsegqdgk gdteetednq testvsqntp aqtegtttet teaapkkecg tsfvmwfgeg
121 vpvaslkcgd ytmvyapekd ktdpapryis gevtsvtfek qestvtikvn nvefstlsts
181 sssptensgs agqvpsrsrr slseeaseta tvdlfaftld ggkrievavp sdedaskrnq
241 yslvaddkpf ytgsnsgatd gifrlnedgd lvdkdnkvll kdagsslq
1 savfsapavp lrgtlkdvsv egssssssss ssssssssss sststvaptp kkertgeevg
61 npgsegqdgk gdteetednq testvsqntp aqtegtttet teaapkkecg tsfvmwfgeg
121 vpvaslkcgd ytmvyapekd ktdpapryis gevtsvtfek qestvtikvn nvefstlsts
181 sssptensgs agqvpsrsrr slseeaseta tvdlfaftld ggkrievavp sdedaskrnq
241 yslvaddkpf ytgsnsgatd gifrlnedgd lvdkdnkvll kdagsslq
First 10 amino acids: Serine, Alanine, Valine, Phenylalanine, Serine, Alanine, Proline,
Alanine, Valine, Proline
Alanine, Valine, Proline
Copy and paste the citation of the paper from which the data are drawn; you will need the authors, title, and journal. If there is more than one reference cited, use only the first.
AUTHORS Peng,X.Q., Tian,G.R., Ren,G.J., Yu,Z.Q., Lok,J.B., Zhang,L.X.,
Wang,X.T., Song,J.K. and Zhao,G.H.
TITLE Infection rate of Giardia duodenalis, Cryptosporidium spp. and
Enterocytozoon bieneusi in cashmere, dairy and meat goats in China
JOURNAL Infect. Genet. Evol. (2016) In press
Wang,X.T., Song,J.K. and Zhao,G.H.
TITLE Infection rate of Giardia duodenalis, Cryptosporidium spp. and
Enterocytozoon bieneusi in cashmere, dairy and meat goats in China
JOURNAL Infect. Genet. Evol. (2016) In press
What is the nucleotide sequence that codes for this protein? Cut and paste from
the database and put these search results (or no more than the first 15 typed lines)
in your post.
the database and put these search results (or no more than the first 15 typed lines)
in your post.
1 tccgctgtat tctcagcccc agccgttcca ctcagaggca ctttaaagga tgtttctgtt
61 gagggttcat catcatcatc atcatcatca tcatcatcat catcatcgtc atcatcatca
121 tcatcaacat cgactgtagc accaactcca aagaaagaaa gaactggaga ggaagtaggt
181 aatccaggtt ctgaaggtca ggacggtaaa ggagacactg aagaaacaga agacaatcag
241 accgagagta ctgtttctca aaatactcca gctcaaactg aaggcacaac taccgaaacc
301 acagaagctg ctccaaagaa agagtgcggt acttcatttg ttatgtggtt cggagagggt
361 gttccagttg catctttgaa gtgtggcgac tatactatgg tctatgcacc agaaaaggac
421 aaaacagatc ccgcaccaag atatatctct ggtgaagtta catctgtaac ctttgaaaaa
481 caagagagca cagttacaat caaggttaat aatgtagagt tcagcactct ttctactagc
541 tcaagtagtc caactgaaaa tagcggatct gcaggtcagg ttccatcaag atcaagaaga
601 tcactctcag aggaggctag tgaaactgca accgtcgatt tgtttgcctt cacccttgat
661 ggtggtaaaa gaattgaagt tgctgtacca agcgacgaag atgcatctaa aagaaaccag
721 tacagtttgg ttgcagacga taaacctttc tataccggct caaatagcgg cgccactgat
781 ggtatcttca ggttgaatga ggacggagac ttggttgaca aggacaacaa agttcttttg
841 aaggatgctg gttcctctct gcaaa
61 gagggttcat catcatcatc atcatcatca tcatcatcat catcatcgtc atcatcatca
121 tcatcaacat cgactgtagc accaactcca aagaaagaaa gaactggaga ggaagtaggt
181 aatccaggtt ctgaaggtca ggacggtaaa ggagacactg aagaaacaga agacaatcag
241 accgagagta ctgtttctca aaatactcca gctcaaactg aaggcacaac taccgaaacc
301 acagaagctg ctccaaagaa agagtgcggt acttcatttg ttatgtggtt cggagagggt
361 gttccagttg catctttgaa gtgtggcgac tatactatgg tctatgcacc agaaaaggac
421 aaaacagatc ccgcaccaag atatatctct ggtgaagtta catctgtaac ctttgaaaaa
481 caagagagca cagttacaat caaggttaat aatgtagagt tcagcactct ttctactagc
541 tcaagtagtc caactgaaaa tagcggatct gcaggtcagg ttccatcaag atcaagaaga
601 tcactctcag aggaggctag tgaaactgca accgtcgatt tgtttgcctt cacccttgat
661 ggtggtaaaa gaattgaagt tgctgtacca agcgacgaag atgcatctaa aagaaaccag
721 tacagtttgg ttgcagacga taaacctttc tataccggct caaatagcgg cgccactgat
781 ggtatcttca ggttgaatga ggacggagac ttggttgaca aggacaacaa agttcttttg
841 aaggatgctg gttcctctct gcaaa
THESE GOATS ARE SO CUTEEEEEE!!!!!!!!! That is so sad to hear about the sick goats. Im curious if you know of any other medications that can solve the issue with Cryptosporidium parvum. I also was shocked that the article wasn't published until 2016. Meaning it is either recent or still evolving.
ReplyDeleteMy vet told me there was no medication for goats but there is for many other animals. She said we just had to wait it out and keep giving him fluids and electrolytes. We gave him Pedialyte everyday.
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