Pikachurin I choose you!
Pikachurin
- The protein I decided to search for was Pikachurin, I picked it solely because of the name because it is, obviously, named after the Pokemon Pickachu
- The specific protein in question is pikachurin isoform 1 precursor [Mus musculus] Chosen because it is found in the common house mouse and well Pikachu looks kind of like a mouse, not here to argue about Pokemon though. This protein affects the photoreceptor ribbon synapses in mice in early embryonic stages. Basically it affects eye to brain info transmission.
- 1 mdlistfslh flllacslpp gavslrtalr ksgkvgppld iklgalncta fsiqwktpkr
61 sgssiigytv fysevgsdks lrershnvpv gqdtliteev igdlkpgtey qvsvaaysqt
121 gkgrlsfprh vttlsqdscl ppaapqqphv lvvsdseval swrpgenegs apiqsysvef
181 irpdfdkswt iiqerlqmds mvikgldpdt nyqfavkamn ahgfsprswp sntvrtlgpg
241 eagsghygpg yitnpgvsed ddgsedeldl dvsfeevkpl patkvgnkkf sveskktsvs
301 nsvmgsrlaq ptsaslhett vaipptpaqr kgknsvamms rlfdmscdet lcsadsfcvn
361 dyawggsrch cnlgkggeac sedifiqypq ffghsyvtfe plknsyqafq vtlefraeae
421 dglllycges ehgrgdfmsl alirrslhfr fncgtgiaii isetkiklga whtvtlyrdg
481 lngmlqlnng tpvtgqsqgq yskitfrtpl ylggapsayw lvratgtnrg fqgcvqslsv
541 ngkkidmrpw plgkalngad vgecssgicd eascihggtc aaikadsyic lcplgfrgrh
601 cedafaltip qfreslrsya atpwplepqh ylsftefeit frpdsgdgvl lysydtgskd
661 flsinmaagh vefrfdcgsg tgvlrseapl tlgqwhdlrv srtakngilq vdkqkvvegm
721 aeggftqikc ntdifiggvp nyddvkknsg ilhpfsgsiq kiilndrtih vkhdftsgvn
781 venaahpcvg apcahggscr prkegyecdc plgfeglncq kecgnhclnt iieaieipqf
841 igrsyltydn pnilkrvsgs rsnafmrfkt takdglllwr gdspmrpnsd fislglrdga
Above is the amino acid coding sequence (first 15 lines)
The first ten amino acids are methionine, aspartic acid, leucine, isoleucine, serine, threonine, phenylalanine, serine, leucine, histidine.
4. Reference:
AUTHORS Nagaya M, Ueno S, Kominami T, Nakanishi A, Koyasu T, Kondo M,
Furukawa T and Terasaki H.
TITLE Pikachurin Protein Required for Increase of Cone Electroretinogram
B-Wave during Light Adaptation
JOURNAL PLoS ONE 10 (6), E0128921 (2015)
Furukawa T and Terasaki H.
TITLE Pikachurin Protein Required for Increase of Cone Electroretinogram
B-Wave during Light Adaptation
JOURNAL PLoS ONE 10 (6), E0128921 (2015)
5. Nucleotide Sequence:
1 attgtaattc catctcctgc gggtcgagcc gccctccctc cggcggccag tgcgtccctc
61 ccctcggctc tcagcgtcca ctccccagcc ccgaaaagcc ttgccgctgc gagcccgctc
121 cgctcaagca cgccagcttc ccaactgctg ccttgcctcc tcggactccc gagtggctcc
181 tggttcagct ccctgggtct cccaccttct catcctcgcg tcactggcgt tccccgcgtc
241 ccccaggaga cgccctttcc ctgcgcgccc gggacttggg gaaactttgc agacgccgtt
301 ggtgagatgg atttaatctc aaccttctcg ctccatttct tgctcctggc ctgcagcctc
361 ccacccggcg ctgtgtcact ccgaacggct ctgcgaaaat caggcaaggt gggacctcct
421 cttgacatca agctgggagc cttgaactgt acagctttca gcatccagtg gaaaacacca
481 aagcgttctg gtagctccat cattggctac acagtgtttt actctgaggt tggttcagat
541 aagtccctgc gggagcggtc acacaacgtc ccggttggcc aggataccct aatcactgag
601 gaagtgattg gagatttgaa gccaggcact gaatatcaag taagcgtagc agcctacagt
661 cagactggca aggggaggct tagcttccct cgacatgtga ccactttgtc tcaagattcc
721 tgcctgcccc ctgcagcacc ccaacagcca catgtccttg tggtttccga ttctgaagtg
781 gccctttctt ggagacctgg agagaatgaa ggaagtgccc caattcagtc ctactctgtg
841 gaattcatta gaccagattt tgacaagagc tggaccataa tccaagagcg cctgcagatg
61 ccctcggctc tcagcgtcca ctccccagcc ccgaaaagcc ttgccgctgc gagcccgctc
121 cgctcaagca cgccagcttc ccaactgctg ccttgcctcc tcggactccc gagtggctcc
181 tggttcagct ccctgggtct cccaccttct catcctcgcg tcactggcgt tccccgcgtc
241 ccccaggaga cgccctttcc ctgcgcgccc gggacttggg gaaactttgc agacgccgtt
301 ggtgagatgg atttaatctc aaccttctcg ctccatttct tgctcctggc ctgcagcctc
361 ccacccggcg ctgtgtcact ccgaacggct ctgcgaaaat caggcaaggt gggacctcct
421 cttgacatca agctgggagc cttgaactgt acagctttca gcatccagtg gaaaacacca
481 aagcgttctg gtagctccat cattggctac acagtgtttt actctgaggt tggttcagat
541 aagtccctgc gggagcggtc acacaacgtc ccggttggcc aggataccct aatcactgag
601 gaagtgattg gagatttgaa gccaggcact gaatatcaag taagcgtagc agcctacagt
661 cagactggca aggggaggct tagcttccct cgacatgtga ccactttgtc tcaagattcc
721 tgcctgcccc ctgcagcacc ccaacagcca catgtccttg tggtttccga ttctgaagtg
781 gccctttctt ggagacctgg agagaatgaa ggaagtgccc caattcagtc ctactctgtg
841 gaattcatta gaccagattt tgacaagagc tggaccataa tccaagagcg cctgcagatg
Well, Pikachu is the Electric Mouse pokemon, so I'd say you nailed it with the fact that it looks like a mouse! On a related note, I believe there is also a Sonic Hedgehog gene.
ReplyDeleteHello!
ReplyDeleteThe Pikachu caught my attention very quickly, so I had to read your blog post! It's fascinating that the scientists who discovered the pikachurin protein decided to name it after Pikachu, who was designed to be a mouse. On a more scientific note, it's pretty neat that this protein plays a significant role in transmitting information from the eyes to the brain. Sometimes I have to remind myself that the relationship between the eyes and brain is so complex - each of them are equally important when it comes to vision! Clearly, pikachurin is very important for mice when it comes to vision and perception.
Hi Jason,
ReplyDeleteIntriguing post!! I have watched this anime when I was a kid but never know why the character looks like that, and it seems like that makes kinda sense for me now haha. Looking at the title of your resource tho, the cone electroretinogram B wave tells why this protein can affect the vision of house mice.
You did well on your post. When I scrolled down and the name caught my attention. I thought to my self that is there such a protein that similar to Pikachu. Anyway, it’s very interesting that not just the name but the roll it plays in the early stage of the house mouse. It can affect to the eyes and brain of the mouse at very early stage. Thank you for sharing the post.
ReplyDelete